Irritable Bowel Syndrome (IBS)

IBS is a set of chronic symptoms associated with the lower gastrointestinal tract. It is usually experienced as abdominal pain, bloating, and discomfort. IBS can include constipation with difficult or painful bowel movements (IBS-c) or it can include diarrhoea due to excess fluid in the colon (IBS-d). While the causes of IBS-c are still in question, lack of colonic motility is thought to be a primary cause. As with chronic constipation, IBS-c can be targeted with naronapride. Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder with worldwide prevalence rates ranging generally in the area of 10–15%. IBS-C is a substantial subset of this larger group, accounting for at least 1.3% of the worldwide population.  
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Reference:
Sperber 2021.